張煥宗  生物醫學系  教授

信箱：changht@mail.cgu.edu.tw 

電話：+886-3-211-8800 ext.3020

最高學歷：愛荷華州立大學博士

專長領域：分析化學和奈米科學

個人/實驗室網頁：https://www.ch.ntu.edu.tw/~htchang/

研究主題

我們團隊致力於綠色合成奈米材料，並將其應用於感測器、細胞影像、藥物、奈米酵素、奈米催化劑及新能源等。研究重點如下：

(I)    金、銀、銅及碳奈米點光學探針的開發

(II)   奈米藥物的合成與其在抗菌、抗凝血和抗癌的應用

(III)  奈米微結構的組裝和應用

(IV)  奈米材料於燃料電池、超級電容及二氧化碳還原的應用

發表著作

已在國際雜誌發表三百九十九篇學術文章，代表著作為:

1. Anand, A.; Jian, H.-J.; Huang, H.-H.; Hean, L.E.; Li, Y.-J.; Lai*, J.-Y.; Chou, H.-D.; Kang, E.Y.-C.; Wu, W.-C.; Lai, C.-C.; Huang, C.-C.; H.-T. Chang* “Anti-angiogenic Carbon Nanovesicles Loaded with Bevacizumab for the Treatment of Age-related Macular Degeneration” Carbon 2023, 2023, 201, 362-370.
2. Lin, Y.-F.; Lin, Y.-S.; Huang, T.-Y.; Wei, S.-C.; Wu, R.-S.; Huang, C.-C.; Huang, Y-F.*; Chang, H.-T.* “Photoswitchable Carbon-dot Liposomes Mediate Catalytic Cascade Reactions for Amplified Dynamic Treatment of Tumor Cells” Journal of Colloid and Interface Sci. 2022, 628, 717–725.
3. Wu, R.-S.; Lin, Y.-S.; Nain, A.; Unnikrishnan, B.; Lin, Y.-F.; Yang, C.-R.; Chen, T.-H.; Huang, Y.-F.*; Huang, C.-C.; Chang, H.-T.* “Evaluation of Chemotherapeutic Response in Living Cells Using Subcellular Organelle‒Selective Amphipathic Carbon Dots” Biosens. Bioelectron. 2022, 211, 114362.
4. Sangili, A.; Unnikrishnan, B.; Nain, A.; Hsu, Y.-J.; Wu, R.-S.; Huang, C.-C. *; Chang, H.-T.* “Stable Carbon Encapsulated Titanium Carbide MXene Aqueous lnk for Fabricating High-performance Supercapacitors” Energy Storage Mater. 2022, 53, 51−61.
5. Lin, W.-J.; Lin, Y.-S.; Chang, H.-T.*; Unnikrishnan, B.; Huang, C.-C.* “Electrocatalytic CuBr@CuO Nanoparticles Based Salivary Glucose Probes” Biosens. Bioelectron. 2021, 194, 113610.
6. Wu, C.-W.; Unnikrishnan, B.; Chen, I.-W. P.; Harroun, S. G.; Chang, H.-T.*; Hung, C.-C.* “Excellent Oxidation Resistive MXene Aqueous Ink for Micro-Supercapacitor Application” Energy Storage Mater. 2020, 25, 563−571.
7. Xu, D.; Lin, Q.*; Chang, H.-T.* “Recent Advances and Sensing Applications of Carbon Dots” Small Methods 2019, 4, 1900387.
8. Chen, T.-H.; Chang, H.-T.* “Stable and Photoswitchable Carbon-Dot Liposome” ACS Appl. Mater. Inter. 2017, 9, 44259–44263.
9. Chen, P.-C.; Periasamy, A. P.; Harroun, S. G.; Wu, W.-P.; Chang, H.-T.* “Photoluminescence Sensing Systems Based on Copper, Gold and Silver Nanomaterials” Coord. Chem. Rev. 2016, 320, 129–138.
10. Chen, W.-Y.; Chang, H.-Y.; Lu, J.-K.; Huang, Y.-C.; Harroun, S. G.; Tseng, Y.-T.; Li, Y.-J.; Huang, C.-C.; Chang, H.-T.* “Self-Assembly of Antimicrobial Peptides on Gold Nanodots: Against Multidrug-Resistant Bacteria and Wound Healing Application” Adv. Funct. Mater. 2015, 25, 7189–7199.
11. Shih, C.-C.; Chen, P.-C.; Lin, G.-L.; Wang, C.-W.; Chang, H.-T.* “Optical and Electrochemical Applications of Silicon–Carbon Dots/Silicon Dioxide Nanocomposites” ACS Nano 2015, 9, 312–319.
12. Hsu, P.-C.; Chang, H.-T.* “Synthesis of High-Quality Carbon Nanodots from Hydrophilic Compounds: Role of Functional Groups” Chem. Commun. 2012, 3984–3986
13. Shiang, Y.-C.; Hsu, C.-L.; Huang, C.-C.*; Chang, H.-T.* “Gold Nanoparticles Presenting Hybridized Self-Assembled Aptamers That Exhibit Enhanced Inhibition of Thrombin” Angew. Chem. Int. Ed. 2011, 50, 7660–7665.
14. Yang, Z.; Chen, C.-Y.; Liu, C.-W.; Li, C.-L.; Chang, H.-T.* “Quantum Dot-Sensitized Solar Cells Featuring CuS/CoS Electrodes Provide 4.1% Efficiency” Adv. Energy Mater. 2011, 1, 259–264.
15. Chiang, C.-K.; Chen, W.-T.; Chang, H.-T.* “Nanoparticle-Based Mass Spectrometry for the Analysis of Biomolecules” Chem. Soc. Rev. 2011, 40, 1269–1281.
16. Lan, G.-Y.; Huang, C.-C.; Chang, H.-T.* “Silver Nanoclusters as Fluorescent Probes for Selective and Sensitive Detection of Copper Ions” Chem. Commun. 2010, 46, 1257–1259.
17. Yang, Z.; Chen, C.-Y.; Liu, C.-W.; Chang, H.-T.* “Electrocatalytic Sulfur Electrodes for CdS/CdSe Quantum Dot–Sensitized Solar Cells” Chem. Commun. 2010, 46, 5485–5487.
18. Huang, C.-C.; Yang, Z.; Lee, K.-H.; Chang, H.-T.* “Synthesis of Highly Fluorescent Gold Nanoparticles for Sensing Mercury(II)” Angew. Chem. Int. Ed. 2007, 46, 6824-6828.
19. Lin, Y.-W.; Tseng, W.-L.*; Chang, H.-T.* “Using a Layer-by-Layer Assembly Technique to Fabricate Multicolored-Light-Emitting Films of CdSe@CdS and CdTe Quantum Dots” Adv. Mater. 2006, 18, 1381-1386.
20. Huang, C.-C.; Chang, H.-T.* “Selective Gold Nanoparticle-Based “Turn-On” Fluorescent Sensors for Detection of Mercury(II) in Aqueous Solution” Anal. Chem. 2006, 78, 8332–8338.

榮譽事項

獲獎：

1. Highly Cited Researchers, Clarivate Analytics 2017, 2018
2. Prof. Rudolph A. Marcus Award 2017
3. Academic Achievement Award, Chinese Chemical Society 2015
4. Fellow of the Royal Society of Chemistry, UK 2013  
5. Y. Z. Hsu Scientific Paper Award, Far Eastern Y. Z. Hsu Science and Technology Memorial Foundation 2008
6. Outstanding Research Award, National Science Council 2007
7. Fu Szu-Nien Award, National Taiwan University 2005
8. Young Scientist Award, College of Science, National Taiwan University 2000
9. Chinese Young Chemist Award, Chinese Chemical Society 2000

雜誌服務：

1. Field Chief Editor: Frontiers in Analytical Science (2021~)
2. Honorable Editor: International Journal of Biosensors & Bioelectronics (IJBSBE) (2016~)
3. Executive Associate Editor: Analytical Sciences (2019~)
4. Associate Editor: Journal of Chinese Chemical Society (2006-2014), Frontiers in Chemistry (Impact Factor: 5.545; 2013~; Analytical); Journal of Food and Drug Analysis (Impact Factor: 6.079; 2018~); Biosensors and Bioelectronics (Impact Factor: 12.545; 2019~)
5. Editorial Advisory Board: Journal of Advanced Research (Impact factor: 12.822; Science; 2014~); JACS Au (2021~)