沈家瑞  醫學生物技術暨檢驗學系 教授兼系主任

信箱： crshen@mail.cgu.edu.tw

電話： 03-2118800 分機3046/5200

最高學歷：英國布里斯托大學病理與微生物學系博士

專長領域：免疫調控、精準檢驗、基因與重組蛋白疫苗、免疫細胞治療

個人/實驗室網頁：https://mip.cgu.edu.tw/p/405-1078-86845,c920.php?Lang=zh-tw

研究主題

1. 探討異位性皮膚炎及自體免疫葡萄膜炎的免疫調控機制，以開發精準檢驗及相關基因、重組蛋白或細胞療法
2. 建立卵巢癌及黑色素瘤動物模式，開發精準檢驗及相關基因、重組蛋白或細胞療法
3. 開發鏡檢及流式細胞分析數據之人工智慧輔助分析平台

發表著作

(五年內代表性十篇)

1. Chen YS, Hwang CH, Liu CL, Chen HS, Wu ST, Lee MH, Shen CR (correspondence). Locally targeting the IL-17/ IL-17RA axis reduced tumor growth in a murine B16F10 melanoma model.  Hum Gene Ther. 2019 Mar; 30(3):273-285. https://doi.org/10.1089/hum.2018.104. SCI=4.793 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY, 24.00%)
2. Barker NM, Li YX, Lee MM, Shen CR, Krause JA, Sun SS, Lu N, Connick WB, and McMillin DR. Synthesis, luminescence, and structure of a polymorphic polyfluorinated diiodoplatinum (II) diimine complex. Inorg Chem. 2019 Aug; 58(16):10716-10724. SCI=5.436 (CHEMISTRY, INORGANIC & NUCLEAR, 10.87%)
3. Elakkat V, Chang CC, Chen JY, Fang YC, Shen CR (correspondence), Liu LK, Lu N. The first two examples of halogen bonding with a sigma hole-donating fluorine in the Csp3–F⋯Osp3 interaction from polyfluorinated trans-dihalo-palladium(II) di-substituted pyridine complexes. Chem Commun (Camb). 2019 Nov; 55(95):14259-14262. SCI=6.065 (CHEMISTRY, MULTIDISCIPLINARY, 29.61%)(MOST108-2320B-182-032)
4. Juang JH, Wang JJ, Shen CR (equal to first), Chen CY, Kao CW, Chen CL, Lin SH, Wu ST, Li WC, Tsai ZT. Magnetic resonance imaging of transplanted porcine neonatal pancreatic cell clusters labeled with chitosan-coated superparamagnetic iron oxide nanoparticles in mice. Polymers 2021 Apr; 13(8):1238. SCI=4.967 (POLYMER SCIENCE, 17.78%)
5. Hsu LJ, Liu CL, Kuo ML, Shen CN, Shen CR (correspondence). An alternative cell therapy for cancers: induced pluripotent stem cell (iPSC)-derived natural killer cells. Biomedicines  2021; 9(10):1323. https://doi.org/10.3390/biomedicines9101323. SCI=6.081 (PHARMACOLOGY & PHARMACY, 31.18%) (MOST 109-2320-B-182-037)
6. Hwang YS, Kang EYC, Shen CR, Hong WH, Wu WC. Noncontact optical measurement of aqueous humor glucose levels and correlation with serum glucose levels in rabbit. Biosensors 2021; 11:387. https://doi.org/10.3390/bios11100387. SCI=5.743 (INSTRUMENTS & INSTRUMENTATION, 12.50%) 
7. Juang JH, Shen CR (equal to first), Wang JJ, Wu ST, Lin SH, Chen CY, Kao CW, Chen CL, Tsai ZT, Wang YM. Exendin-4-conjugated manganese magnetism-engineered iron oxide nanoparticles as a potential magnetic resonance imaging contrast agent for tracking transplanted b-cells. Nanomaterials 2021; 11:3145. https://doi.org/10.3390/nano11113145. SCI=5.719 (PHYSICS, APPLIED, 22.98%) 
8. Shen CR, Chen YS, Hwang YS, Chen HJ, Liu CL. Differential bicistronic gene translation mediated by the internal ribosome entry site element of encephalomyocarditis virus. Biomed J. 2021; 44(6):S54-S62. doi:10.1016/j.bj.2020.06.006. SCI=7.892 (BIOCHEMISTRY & MOLECULAR BIOLOGY, 15.829%)
9. Lo SM, Hwang YS, Liu CL, Shen CN, Hong WH, Yang WC, Lee MH, Shen CR (correspondence). Inhibiting TLR7 expression in the retinal pigment epithelium suppresses experimental autoimmune uveitis. Front Immunol. 2022; 12:736261. https://doi.org/10.3389/fimmu.2021.736261. SCI=8.787 (IMMUNOLOGY, 21.60%) (MOST 109-2320-B-182-037)
10. Juang JH, Wang JJ, Shen CR (equal to first), Lin SH, Chen CY, Kao CW, Chen CL, Wu ST, Tsai ZT, Wang YM. Magnetic Resonance Imaging of Transplanted Porcine Neonatal Pancreatic Cell Clusters Labeled with Exendin-4-Conjugated Manganese Magnetism-Engineered Iron Oxide Nanoparticles. Nanomaterials 2022; 12(7):1222. https://doi.org/10.3390/nano12071222. SCI=5.719 (PHYSICS, APPLIED, 22.98%) 

榮譽事項

2020 國立成功大學醫學院傑出校友

2020經濟工業局109年度「AI智慧應用新世代人才培育計畫」人才解題實證特優獎、佳作獎

2018醫檢學會107年度學生論壇第一名(擔任共同指導老師)

2018科技部106年度大專學生研究計畫研究創作獎(擔任指導老師)

2017科技部105年度大專學生研究計畫研究創作獎(擔任指導老師)

2015長庚大學104年度優良教師教學獎

中華民國台灣人工智慧應用發展協會 (理事2019-2022；常務監事2023-迄今)

中華民國免疫學會 (理事2012-2018)

台灣幾丁質幾丁聚醣學會 (理事2008- present)