賴銘志   生物醫學系 副教授

信箱：mclai@mail.cgu.edu.tw

電話：+886-3-211-8800 ext.3354

最高學歷：國防醫學院生命科學所 博士

專長領域：核酸代謝、癌症研究及分子病毒

個人/實驗室網頁：

https://ls.cgu.edu.tw/p/412-1073-6136.php?Lang=zh-tw

研究主題

1. 研究DEAD-box RNA解旋酶DDX3的生物功能

2. 研究大腸癌細胞在缺氧環境下的轉譯調控機制

3. 改善CHO細胞的蛋白質產能(產學合作)

發表著作

1. Ming-Chih Lai*, Yi-Pin Chen, Ding-An Li, Jau-Song Yu, Hsin-Yuan Hung, Woan-Yuh Tarn*. (2022) DDX3 interacts with USP9X and participates in deubiquitination of the anti-apoptotic protein MCL1. FEBS J. 289: 1043-1061. (SCI, 2021 IF= 5.622, Ranking 88/297 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
2. Ming-Chih Lai, Han-Hsiang Chen, Peng Xu, Robert YL Wang*. (2020). Translation control of Enterovirus A71 gene expression. Journal of Biomedical Science 27(1):22 (SCI, 2021 IF= 12.771, Ranking 24/195 in CELL BIOLOGY)
3. Tsung-Ming Chen, Ming-Chih Lai, Yi-Han Li, Ya-Ling Chan, Chih-Hao Wu, Yu-Ming Wang, Chun-Wei Chien, San-Yuan Huang, H. Sunny Sun*, Shaw-Jenq Tsai*. (2019). hnRNPM induces translation switch under hypoxia to promote colon cancer development. EBioMedicine 41: 299-309 (SCI, 2021 IF= 11.205, Ranking 14/139 in MEDICINE, RESEARCH & EXPERIMENTAL)
4. Yu-Chang Ku, Min-Hua Lai, Chen-Chia Lo, Yi-Chuan Cheng, Jian-Tai Qiu, Woan-Yuh Tarn, Ming-Chih Lai*. (2019). DDX3 participates in translational control of inflammation induced by infections and injuries. Mol. Cell. Biol. 39(1): e00285-18 (SCI, 2021 IF= 5.094, Ranking 106/297 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
5. Jeng-Ting Chen, Chien-Chun Liu, Jau-Song Yu, Hung-Hsuan Li, Ming-Chih Lai*. (2018). Integrated omics profiling identifies hypoxia-regulated genes in HCT116 colon cancer cells. J. Proteomics 188: 139-151 (SCI, 2021 IF= 3.855, Ranking 28/79 in BIOCHEMICAL RESEARCH METHODS)
6. Ming-Chih Lai*, Chiao-May Chang, H. Sunny Sun*. (2016). Hypoxia induces autophagy through translational up-regulation of lysosomal proteins in human colon cancer cells. PLOS ONE 11(4): e0153627 (SCI, 2021 IF= 3.752, Ranking 29/74 in MULTIDISCIPLINARY SCIENCES)
7. Ming-Chih Lai*, H. Sunny Sun, Shainn-Wei Wang, Woan-Yuh Tarn*. (2016). DDX3 functions in antiviral innate immunity through translational control of PACT. FEBS J. 283(1): 88-101 (SCI, 2021 IF= 5.622, Ranking 88/297 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

榮譽事項

1. 第十六屆細胞及分子生物新知研討會 壁報論文獎
2. 第一屆永信李天德醫藥科技獎--傑出論文獎 & 董事長特別獎
3. 八十九學年度國科會研究獎勵(乙種)
4. 八十八學年度國科會研究獎勵(乙種)