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洪麗滿

 

洪麗滿  生物醫學系 教授

洪麗滿

信箱：lisahung@mail.cgu.edu.tw

電話：3338

最高學歷：博士

專長領域：心血管學、生理、藥理及生理

個人/實驗室網頁：

研究主題

計劃名稱：胞外小體微小RNA在糖尿病性心衰竭中扮演之病生理角色

開始日期： 2022/1/1 結束日期： 2022/12/31    

     

計劃名稱：CCL5-Ceramide迴路在高脂飲食造成胰島素阻抗與β細胞功能障礙之角色(1/

開始日期： 2022/7/1 結束日期： 2024/6/30

 

計劃名稱：研究肥胖中心臟與脂肪組織之交互作用- 利鈉肽在能量利用與心臟功能之角色

開始日期： 2023/1/1 結束日期： 2024/12/31

 

計劃名稱：探索CCR5訊息在肥胖相關的能量代謝失調和免疫代謝異常發展中的組織特異性作用-CCR5協調控制心臟與脂肪組織間的溝通於心臟生理與肥胖性心肌病變中扮演之角色

開始日期： 2021/8/1 結束日期： 2024/7/31

發表著作
  1. Huang JP, Chang CC, Kuo CY, Huang KJ, Sokal EM, Chen KH, Hung LM* (correspondence), Exosomal microRNAs miR-30d-5p and miR-126a-5p Are Associated with Heart Failure with Preserved Ejection Fraction in STZ-Induced Type 1 Diabetic Rats. Int J Mol Sci. 6;23(14): 7514. 2022.
  2. Chan PC, Hung LM, Huang JP, Day YJ, Yu CL, Kuo FC, Lu CH, Tian YF, Hsieh PS. Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity. Clin Sci (Lond). 14;136(1):121-137. 2022
  3. Chu WK, Hung LM, Hou CW, Chen JK. MicroRNA 630 Represses NANOG Expression through Transcriptional and Post-Transcriptional Regulation in Human Embryonal Carcinoma Cells. Int J Mol Sci. 21;23(1):46. 2022
  4. Ma H, Zhang F, Zhou L, Cao T, Sun D, Wen S, Zhu J, Xiong Z, Tsau MT, Cheng ML, Hung LM, Zhou Y, Li Q. c-Src facilitates tumorigenesis by phosphorylating and activating G6PD. Oncogene. 40(14):2567-2580, 2021
  5. Yu-Hao Liu , Chien-Chang Chen , Yi-Jen Hsueh , Hung LM, David Hui-Kang Ma, Hung-Chi Chen, Wen-Bin Len, Yaa-Jyuhn J Meir. Extraneous E-Cadherin Engages the Deterministic Process of Somatic Reprogramming through Modulating STAT3 and Erk1/2 Activity. Cells. 31;10(2):284. 2021
  6. Chu WK, Hung LM, Hou CW, Chen JK. PKC Regulates YAP Expression through Alternative Splicing of YAP 3'UTR Pre-mRNA by hnRNP F.  Int J Mol Sci. 12;22(2):E694. 2021
  7. Huang JP, Cheng ML, Wang CH, Huang SS, Hsieh PS, Chang CC, Kuo CY, Chen KH, Hung LM* (correspondence). Therapeutic potential of cPLA2 inhibitor to counteract dilated-cardiomyopathy in cholesterol-treated H9C2 cardiomyocyte and MUNO rat. Pharmacol Res. 2020 Oct;160:105201
  8. Chang CC, Chang CY, Lin PC, Huang JP, Chen KH, Yen TH, Hung LM* (correspondence), Administration of low-dose resveratrol attenuated hepatic inflammation and lipid accumulation in high cholesterol-fructose diet-induced rat model of nonalcoholic fatty liver disease. Chin J Physiol. 63(4):149-155, 2020.
  9. Ma H, Zhang J, Zhou L, Wen S, Tang HY, Jiang B, Zhang F, Suleman M, Sun D, Chen A, Zhao W, Lin F, Tsau MT, Shih LM, Xie C, Li X, Lin D, Hung LM* (correspondence), Cheng ML, Li Q. c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3. Cell Rep. 24;30(12)：4235-4249, 2020.
  10. Chan YH, Chang GJ, Lai YJ, Chen WJ, Chang SH, Hung LM, Kuo CT, Yeh YH. Atrial fibrillation and its arrhythmogenesis associated with insulin resistance. Cardiovasc Diabetol.  26;18(1):125, 2019.
  11. Huang JP, Hsu SC, Li DE, Chen KH, Kuo CY, Hung LM* (correspondence). Resveratrol Mitigates High-Fat Diet-Induced Vascular Dysfunction by Activating the Akt/eNOS/NO and Sirt1/ER Pathway. Journal of Cardiovascular Pharmacology. 72(5):231-241, 2018.
  12. Chu WK, Hung LM, Hou CW, Chen JK. Heterogeneous ribonucleoprotein F regulates YAP expression via a G-tract in 3'UTR. Biochim Biophys Acta Gene Regul Mech. S1874-9399 (18)30174-3, 2018.
  13. Chung YH, Lu KY, Chiu SC, Lo CJ, Hung LM, Huang JP, Cheng ML, Wang CH, Tsai CK, Lin YC, Chang SH, Lin G. Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer. Contrast Media Mol Imaging.  Jul 12;2018
  14. Huang JP, Hsu SC, Meir YJ, Hsieh PS, Chang CC, Chen KH, Chen JK, Hung LM* (correspondence). Role of dysfunctional adipocytes in cholesterol-induced nonobese metabolic syndrome. J Mol Endocrinol. 60(4)：307-321, 2018.
  15. Yang Z, Jiang B, Wang Y, Ni H, Zhang J, Xia J, Shi M, Hung LM, Ruan J, Mak TW, Li Q, Han J. 2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter. Cell Rep. 30;19(9)：1846-1857, 2017.
  16. Jiang B, Zhang J, Xia J, Zhao W, Wu Y, Shi M, Luo L, Zhou H, Chen A, Ma H, Zhao Q, Suleman M, Lin F, Zhou L, Wang J, Zhang Y, He Y, Li X, Hung LM, Mak TW, Li Q. IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation. Cell Rep. 11;19(2)：389-400, 2017.
  17. Huang JP, Cheng ML, Hung CY, Wang CH, Hsieh PS, Shiao MS, Chen JK, Li DE, Hung LM*(correspondence). Docosapentaenoic acid and docosahexaenoic acid are positively associated with insulin sensitivity in rats fed high-fat and high-fructose diets. Journal of Diabetes.  9(10)：936-946, 2017.
  18. Jiung-Pang Huang, Mei-Ling Cheng, Chao-HungWang, Ming-Shi Shiao, Jan-Kan Chen & Hung LM*(correspondence). High-fructose and high-fat feeding correspondingly lead to the development of lysoPC-associated apoptotic cardiomyopathy and adrenergic signaling-related cardiac hypertrophy. International Journal of Cardiology. 215 (2016): 65–76, 2016.
  19. Chih-Chun Chang, Keng-Yang Lin, Kang-Yu Peng, Yuan-Ji Day & Hung LM* (correspondence). Resveratrol exerts anti-obesity in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells. Endocrine Journal. 63 (2): 169-78, 2016.
  20. Hung LM, Huang JP, Liao JM, Yang MH, Li DE, Day YJ, Huang SS. Insulin renders diabetic rats resistant to acute ischemic stroke by arresting nitric oxide reaction with superoxide to form peroxynitrite. Journal of Biomedical Science 18 (1): 47, 2014.
  21. Chang CC, Yang MH, Tung HC, Chang CY, TSAI YL, Huang JP, YEN TH & Hung LM* (correspondence). Resveratrol exhibits differential protective effects on fast- and slow-twitch muscles in streptozotocin-induced diabetic rats. Journal of Diabetes6 (1): 60-7, 2014
  22. Huang SS, Lu YJ, Huang JP, Wu YT, Day YJ & Hung LM* (correspondence). The essential role of eNOS activation in insulin-mediated neuroprotection against ischemic stroke in diabetes. Journal of Vascular Surgery59 (2): 483-91, 2014.
  23. Chang CC, Chang CY, Huang JP & Hung LM* (correspondence). The Effect of Resveratrol on oxidative and inflammatory stress in liver and spleen of streptozotocin-induced type 1 diabetic rats. Chinese Journal of Physiology, 55 (x), 2012.
  24. Liao PH, Hung LM (co-first author), Chen YH, Kuan YH, Zhang FBY, Lin RH, Shih HC, Tsai SK, Huang SS. Cardioprotective effects of luteolin during ischemia/reperfusion injury in rats. Circulation Journal 75(2):443-450, 2012.
  25. Chang CC, Chang CY, Wu YT, Huang JP, Yen TH & Hung LM* (correspondence). Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase. Journal of Biomedical Science 18 (1): 47, 2011.
  26. Huang JP, Huang SS, Deng JY, Day YJ & Hung LM* (correspondence). Insulin and resveratrol act synergistically preventing cardiac dysfunction in diabetes but the advantage of resveratrol in diabetics with acute heart attack is antagonized by insulin. Free Radical Biology and Medicine 49(11):1710-1721, 2010.
  27. Hsieh YH, Huang SS, Day YJ, Wei FC & Hung LM* (correspondence). Involvement of YC-1 in Extracellular Signal-Regulated Kinases action really interesting in cremasteric muscle. Journal of Pharmacy and Pharmacology 62(2):1746-1752, 2010.
  28. Huang JP, Huang SS, Deng JY & Hung LM* (correspondence). Impairment of insulin-stimulated Akt/GLUT4 signaling is associated with cardiac contractile dysfunction and aggravates I/R injury in STZ-diabetic Rats. Journal of Biomedical Science 16 (1): 77, 2009.
  29. Chen WP, Hung LM, Hsueh CH, Lai LP & Su MJ. Piceatannol, a derivative of resveratrol, moderately slows I(Na) inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. British Journal of Pharmacology 157(3):381-391, 2009.
  30. Lin JY, Hung LM, Lai LY & Wei FC. Kappa-opioid receptor agonist protects the microcirculation of skeletal muscle from ischemia reperfusion injury. Annals of Plastic Surgery, 61(3): 330-336, 2008.
  31. Deng JY, Hsieh PS, Huang JP, Lu Ls & Hung LM* (correspondence). Activation of Estrogen Receptor is Crucial for Resveratrol-stimulating Muscular Glucose Uptake via Both Insulin-dependent and Independent Pathways. Diabetes, 57(7): 1814-1823, 2008.
  32. Tsai SK, Hung LM (co-first author), Fu YT, Cheng H, Nien MW, Liu HY, Zhang FB & Huang SS. Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats. Journal of Vascular Surgery, 46(2): 346-353, 2007. (IF: 2.980)
  33. Deng JY, Huang JP, Lu Ls & Hung LM* (correspondence). Impairment of cardiac insulin signaling and myocardial contractile performance in high cholesterol-fructose fed rats. American Journal of Physiology-Heart and Circulatory Physiology, 293(2):H978-H987, 2007.
  34. Lu LS, Hung LM, Liao CH, Wu CC & Su MJ. Effects of rosiglitazone on native low-density-lipoprotein-induced respiratory burst in circulating monocytes and on the leukocyte-endothelial interaction in cholesterol-fed rats. Naunyn-Schmiedebergs Archives of Pharmacology, 375(4): 251-260, 2007.
  35. Lu LS, Wu CC, Hung LM, Chiang MT, Lin CT, Lin CW & Su MJ. Apocynin alleviated hepatic oxidative burden and reduced liver injury in hypercholesterolaemia. Liver International, 27(4): 529-537, 2007.
  36. Hsieh YH, Huang SS, Wei FC & Hung LM* (correspondence). Resveratrol attenuates ischemia-reperfusion induced leukocyte-endothelial cell adhesive interactions and prolongs allograft survival across MHC barrier. Circulation Journal, 71(3): 423-428, 2007.
  37. Chen WP, Su MJ & Hung LM* (correspondence). In vitro electrophysiological mechanisms for antiarrhythmic efficacy of resveratrol, a natural antioxidant derived from grapes. European Journal of Pharmacology, 554(2-3): 196-204, 2007.
  38. Huang SS, Wei FC & Hung LM* (correspondence). Ischemic preconditioning attenuated postischemic leukocyte-endothelial cell adhesive interactions: the role of nitric oxide and protein kinase C.  Circulation Journal 70(8): 1070-1075, 2006.
  39. Ulusal BG, Ulusal AE, Hung LM & Wei FC. The Effect of A(2A) Adenosine Receptor Agonist on Composite Tissue Allotransplant Survival: An In Vivo Preliminary Study.  Journal of Surgical Research 131(2): 261-266, 2006.
  40. Su HC, Hung LM (co-first author), & Chen JK. Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats.  American Journal of Physiology- Endocrinology and Metabolism 290(6): E1339-1346, 2006.
  41. Ulusal AE, Ulusal BG, Hung LM & Wei FC. Temporary assisting suspension suture technique for successful microvascular anastomosis of extremely small and thin walled vessels for mice transplantation surgery.  Plastic and Reconstructive Surgery 116(5): 1438-1441, 2005.
  42. Ulusal AE, Ulusal BG, Hung LM & Wei FC. Establishing a composite auricle allotransplantation model in rats: introduction to transplantation of facial subunits. Plastic and  Reconstructive Surgery 116(3): 811-817, 2005.
  43. Ulusal AE, Ulusal BG, Hung LM & Wei FC. Heterotopic hindlimb allotransplantation in rats: An alternative model for immunological research in composite-tissue allotransplantation. Microsurgery 25(5): 410-414, 2005.
  44. Wei W, Wei FC & Hung LM* (correspondence). Diazoxide ameliorates microcirculatory disturbances through PKC-dependent pathway in I/R injured rat cremaster muscles. Journal of Biomedical Science 12 (3): 521-529, 2005.
  45. Ulusal BG, Ulusal AE, Yazar S, Chang CH, Hung LM & Wei FC. Pectoral skin flap as a reliable and simple model for vascularized composite skin transplantation research. Journal of Reconstructive Microsurgery 21(3):187-190, 2005.
  46. Ulusal BG, Ulusal AE, Hung LM & Wei FC. Usefulness of combined continuous suture and interrupted tie technique in hindlimb composite tissue allotransplantation in rats. Microsurgery 25(1):80-82, 2005.
  47. Hung LM, Wei W, Hsueh YJ, Chu WK & Wei FC. Ischemic preconditioning ameliorates microcirculatory disturbance through downregulation of TNF-production — rat cremaster muscles model.  Journal of Biomedical Science 11(6): 773-780, 2004.
  48. Ulusal BG, Ulusal AE, Hung LM & Wei FC. Local anesthesia saves lives of experimental rats and time and money of researchers in composite tissue allotransplantation. Plastic and  Reconstructive Surgery 114(6): 1689-1691, 2004.
  49. Hung LM, Su MJ & Chen JK. Resveratrol protect myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms. Free Radical Biology and Medicine 36(6): 774-781, 2004.
  50. Chang GJ, Su MJ, Hung LM & Lee SS. Cardiac electrophysiologic and antiarrhythmic actions of a pavine alkaloid derivative, O-methyl-neocaryachine, in rat heart. British Journal of Pharmacology 136(3): 459-471, 2002.
  51. Hung LM, Su MJ, Chu WK, Chiao CW, Chan WF & Chen JK. The protective effect of resveratrols on ischemia-reperfusion injuries of the rat hearts is correlated with antioxidant efficacy. British Journal of Pharmacology 135(7): 1627-1633, 2002.
  52. Hung LM, Lee SS, Chen JK, Huang SS & Su MJ. Thaliporphine protects ischemic and ischemic rat hearts via NO-dependent mechanism. Drug Development Research 52:446-453, 2001.
  53. Hung LM, Chen JK, Lee RS, Liang HC & Su MJ. Beneficial effects of astringinin, a resveratrol analogue, on the ischemia and reperfusion damage in rat heart. Free Radical Biology & Medicine 30(8): 877-883, 2001.
  54. Huang SS, Tsai MC, Chih CL, Hung LM & Tsai SK. Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia. Life Sciences 69(9): 1057-1065, 2001.
  55. Hung LM, Chen JK, Huang SS, Lee RS & Su MJ. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovascular Research 47(3): 549-555, 2000.
  56. Tsai SK, Huang CH, Huang SS, Hung LM & Hong CY. Antiarrhythmic effect of magnolol and honokiol during acute phase of coronary occlusion in anesthetized rats: influence of L-NAME and aspirin. Pharmacology 59(5): 227-233, 1999.
  57. Chang SC, Liao YF, Hung LM, Tseng CS, Hsu JH & Chen JK. Prefabricated implants or grafts with reverse models of three-dimensional mirror-image templates for reconstruction of craniofacial abnormalities. Plastic and Reconstructive Surgery 104(5):1413-1418, 1999.
  58. Hung LM, Tsai CH & Chen JK. TGF-beta1 selectively suppresses PDGF receptor signaling pathways in MG-63 human osteosarcoma cell. Life Sciences 61(7):685-693, 1997.
  59. Tsai CH, Hung LM, Cheng HP & Chen JK. Increased intracellular cyclic AMP levels suppress the mitogenic responses of human astrocytoma cells to growth factors. Journal of Neuro-Oncology 23(1):41-52, 1995.
  60. Tsai CH, Hung LM & Chen JK. Perturbation of the platelet-derived growth factor receptor signaling by dibutyryl-cAMP in human astrocytoma cells. Journal of Cellular Physiology 164(1):108-116, 1995.

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